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Gene therapy
How gene editing is helping fight disease
BBC 3 December 2015
How gene editing is helping fight disease
Video BBC News 3 December 2015
Gene editing - the ability to manipulate our
DNA -
is set to transform the way we battle
disease.
It offers the hope that inherited genetic
conditions
could be treated, and perhaps even cured.
Scientists from all over the world
have
gathered in Washington
to discuss the potential of the technique.
Fergus Walsh reports.
YouTube
https://www.youtube.com/watch?v=bfqLD7iTR0U
Human Genome Editing: Hopes and Fears
WoodrowWilsonCenter
18 August 2015
Human Genome Editing: Hopes and Fears
Video
WoodrowWilsonCenter
18 August 2015
Breakthroughs in the process of editing the
human genome
have scientists both "excited and
terrified."
What are the potential benefits and risks
associated with altering human DNA
and is science and society
prepared for the
ethical, moral,
and policy questions raised
by new
technological capabilities?
Public Policy Scholar Eleonore Pauwels helps
us consider
the implications of controlling the
biological process
in this edition of Wilson Center NOW.
WoodrowWilsonCenter
https://www.youtube.com/watch?v=-sU2HrmZ-7s
DNA >
Species-wide Gene Editing > Gene
drive USA
A
revolutionary technology
known as
“gene drive”
(...)
for the first time gives humans
the power
to alter or perhaps eliminate
entire
populations of organisms in the wild
http://www.nytimes.com/2016/06/09/
science/national-academies-sciences-gene-drive-technology.html
http://www.nytimes.com/2016/06/09/
science/national-academies-sciences-gene-drive-technology.html
http://www.npr.org/sections/health-shots/2016/06/08/
481234642/new-genetic-engineering-method-called-promising-and-perilous
http://www.nytimes.com/2015/12/22/
science/gene-drives-offer-new-hope-against-diseases-and-crop-pests.html
http://www.npr.org/sections/health-shots/2015/11/05/
451216596/powerful-gene-drive-can-quickly-change-an-entire-species
edit
manipulate genes
delete
cut
remove
repair / fix
editing
heritable human genes USA
http://www.npr.org/sections/health-shots/2017/02/14/
514580162/scientific-panel-says-editing-heritable-human-genes-could-be-ok-in-the-future
edit DNA
USA
http://www.npr.org/sections/health-shots/2017/08/02/
540975224/scientists-precisely-edit-dna-in-human-embryos-to-fix-a-disease-gene
http://www.nytimes.com/2014/03/04/
health/a-powerful-new-way-to-edit-dna.html
edit DNA > technique > prime editing
USA
https://www.npr.org/sections/health-shots/2019/10/21/
771266879/scientists-create-new-more-powerful-technique-to-edit-genes
treat cancer by editing genes
USA
https://www.npr.org/sections/health-shots/2018/02/21/
585336506/doctors-in-china-lead-race-to-treat-cancer-by-editing-genes
gene therapy > CAR-T
cancer therapy USA
https://www.npr.org/sections/health-shots/2018/07/17/
629543151/insurers-and-government-are-slow-to-cover-expensive-car-t-cancer-therapy
editing embryo DNA / genome editing
USA / UK
edit DNA in human embryos
to fix a disease gene
http://www.npr.org/sections/health-shots/2017/09/20/
551779921/editing-embryo-dna-yields-clues-about-early-human-development
http://www.npr.org/sections/health-shots/2017/08/18/
543769759/a-first-look-inside-the-lab-where-scientists-are-editing-dna-in-human-embryos
https://www.theguardian.com/commentisfree/2017/aug/03/
gene-editing-mitochondrial-replacement-therapy-designer-babies
https://www.nytimes.com/2017/08/02/
science/gene-editing-human-embryos.html
http://www.npr.org/sections/health-shots/2017/08/02/
540975224/scientists-precisely-edit-dna-in-human-embryos-to-fix-a-disease-gene
https://www.theguardian.com/science/2017/aug/02/
deadly-gene-mutations-removed-from-human-embryos-in-landmark-study
edit genes to
treat disease USA
http://www.npr.org/sections/health-shots/2017/08/10/
542659066/people-back-editing-genes-to-treat-disease-but-are-wary-of-inheritable-changes
change traits
USA
http://www.npr.org/sections/health-shots/2017/08/10/
542659066/people-back-editing-genes-to-treat-disease-but-are-wary-of-inheritable-changes
edit genes of human embryos
USA
http://www.nytimes.com/2015/04/24/
health/chinese-scientists-edit-genes-of-human-embryos-raising-concerns.html
edit DNA of healthy human embryos
USA
http://www.npr.org/sections/health-shots/2016/09/22/
494591738/breaking-taboo-swedish-scientist-seeks-to-edit-dna-of-healthy-human-embryos
edit DNA In human embryos
USA
http://www.npr.org/sections/health-shots/2015/09/18/
441408880/british-scientists-seek-permission-to-edit-dna-in-human-embryos
genetic
engineering USA
http://www.npr.org/sections/health-shots/2016/06/08/
481234642/new-genetic-engineering-method-called-promising-and-perilous
http://www.npr.org/sections/health-shots/2015/11/05/
451216596/powerful-gene-drive-can-quickly-change-an-entire-species
genetic
enhancements UK
https://www.theguardian.com/commentisfree/2016/aug/28/
ideology-liberal-democracy-technology-bioscience-yuval-harari-artificial-intelligence
genome editing
Ethics of Genome Editing.
Questions on Medical Treatments and the Impact on
Future Generations
video - UNESCO- 20 October 2020
https://www.youtube.com/watch?v=a2wd8jqW5fM
Genome
editing:
how to
modify
genetic faults – and the human germline
UK 2 September 2015
Is it time for a
debate
on whether there are
any circumstances
where there is an
ethical case
for ‘editing’ human embryos?
http://www.theguardian.com/science/2015/sep/02/
genome-editing-how-to-modify-genetic-faults-and-the-human-germline
genetically
modified / engineered immune cells > 'living drugs'
USA
https://www.npr.org/sections/health-shots/2018/09/14/
646754993/update-a-young-mans-experiment-with-a-living-drug-for-leukemia
gene editing
UK
https://www.theguardian.com/science/
gene-editing
https://www.theguardian.com/science/audio/2023/mar/16/
how-will-gene-editing-change-medicine-
and-who-will-benefit-podcast - Guardian podcast
https://www.theguardian.com/science/2023/feb/26/
does-gene-editing-hold-the-key-to-improving-mental-health
https://www.theguardian.com/science/2023/feb/05/
how-far-should-we-go-with-gene-editing-in-pursuit-of-the-perfect-human
https://www.theguardian.com/commentisfree/2017/aug/03/
gene-editing-mitochondrial-replacement-therapy-designer-babies
gene editing
USA
https://www.nytimes.com/2018/07/11/
health/gene-editing-cancer.html
https://www.npr.org/sections/health-shots/2017/12/20/
571208704/scientists-use-gene-editing-to-prevents-a-form-of-deafness-in-mice
http://www.npr.org/sections/health-shots/2017/01/01/
507244429/unexpected-risks-found-in-editing-genes-to-prevent-inherited-disorders
https://www.npr.org/sections/health-shots/2016/05/18/
478212837/in-search-for-cures-
scientists-create-embryos-that-are-both-animal-and-human
http://www.nytimes.com/2016/01/01/
science/gene-therapy-muscular-dystrophy.html
http://www.nytimes.com/2015/11/15/
magazine/the-crispr-quandary.html
http://www.npr.org/sections/health-shots/2014/10/13/
354934248/in-hopes-of-fixing-faulty-genes-one-scientist-starts-with-the-basics
a way to efficiently and precisely remove genes
from white blood
cells of the immune system
and to
insert beneficial replacements
USA
https://www.nytimes.com/2018/07/11/
health/gene-editing-cancer.html
gene editing in
animals USA
http://www.nytimes.com/2015/11/27/us/
2015-11-27-us-animal-gene-editing.html
editing human
genes USA
http://www.npr.org/sections/health-shots/2015/12/03/
458212497/scientists-debate-how-far-to-go-in-editing-human-genes
designer baby USA
https://www.npr.org/sections/health-shots/2019/05/02/
719665841/why-making-a-designer-baby-would-be-easier-said-than-done
https://www.npr.org/sections/health-shots/2019/02/01/
689623550/new-u-s-experiments-aim-to-create-gene-edited-human-embryos
https://www.nytimes.com/2018/06/10/
us/11retro-baby-genetics.html
http://www.npr.org/sections/health-shots/2017/02/14/
514580162/scientific-panel-says-editing-heritable-human-genes-could-be-ok-in-the-future
designer babies /
making embryos in a lab USA
http://www.npr.org/sections/health-shots/2016/06/16/
482189322/will-baby-making-move-from-the-bedroom-to-the-lab
http://www.npr.org/sections/health-shots/2015/12/03/
458212497/scientists-debate-how-far-to-go-in-editing-human-genes
better babies
USA
https://www.nytimes.com/2018/06/10/us/11
retro-baby-genetics.html
baby with 3
genetic parents USA
Last fall,
the New
York-based reproductive
endocrinologist
John Zhang
made headlines
when he reported
the birth of the
world's
first "three-parent" baby
— a healthy boy
carrying the blended DNA
of the birth
mother, her husband
and an unrelated
female donor.
The technique,
called
mitochondrial replacement therapy,
allowed the
36-year-old mother
to bypass a
defect in her own genome
that had led,
twice before,
to children born
with Leigh syndrome,
a devastating
neurological disorder
that typically
culminates in death
before age 3.
While heralded in
many circles
as a breakthrough,
the news
triggered
numerous ethical
and scientific questions,
many of which
remained
unanswered at the time.
Last week,
Zhang and his
colleagues
at the New Hope Fertility Center
provided some
answers
— and raised yet more concerns.
http://www.npr.org/sections/health-shots/2017/04/08/
523020895/a-baby-with-3-genetic-parents-seems-healthy-but-questions-remain
gene therapy
UK
http://www.guardian.co.uk/science/2013/apr/30/
gene-therapy-trials-heart-patients
http://www.guardian.co.uk/science/2000/jun/26/
genetics.drugs
gene therapy
USA
https://www.npr.org/sections/health-shots/2023/05/02/
1171357002/gene-therapy-for-muscular-dystrophy-stirs-
hopes-and-controversy
https://www.npr.org/sections/health-shots/2020/07/27/
893289171/a-boy-with-muscular-dystrophy-was-headed-for-a-wheelchair-
then-gene-therapy-arri
https://www.npr.org/sections/health-shots/2019/04/17/
714121698/gene-therapy-advances-to-better-treat-bubble-boy-disease
https://www.npr.org/sections/health-shots/2018/04/18/
602914728/gene-therapy-for-inherited-blood-disorder-reduced-transfusions
http://www.npr.org/sections/health-shots/2015/07/08/
421204204/genetic-tweaks-are-restoring-hearing-in-animals-raising-hopes-for-people
https://www.npr.org/sections/health-shots/2013/12/07/
249335960/gene-therapy-keeps-bubble-boy-disease-at-bay-in-8-children
pioneering treatment > replacement
gene UK
http://www.guardian.co.uk/science/2013/apr/30/
gene-therapy-trials-heart-patients
gene therapy > Parkinson's disease
UK
http://www.theguardian.com/uk/2006/oct/18/
genetics.science
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