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Gene editing
CRISPR
How to defeat malaria
The Economist 25 April 2019
How to defeat malaria
Video The Economist
25 April 2019
Malaria still kills around 400,000
people a year.
Efforts to eradicate the disease
have stalled because of drug resistance
—but pioneering gene-editing
technology might offer a new solution
YouTube
https://www.youtube.com/watch?v=bm9P5eXtmqw
Crispr-Cas9 explained:
the biggest revolution in gene editing
G 28
March 2019
Crispr-Cas9 explained: the biggest revolution in gene editing
Video
The Guardian
28 March 2019
Professor Jennifer Doudna,
one the pioneers of Crispr-Cas9 gene editing
explains
how this important discovery
enables precise changes to our DNA,
which
can be used to correct mutations
that cause genetic disease
and
completely eradicate it from a germline.
Doudna
raises the 4 key issues of debate
around
this revolutionary discovery
and
suggests what will have the most immediate impact.
YouTube
https://www.youtube.com/
watch?time_continue=261&v=_PU5bCflzEM
Biologist Explains One Concept
in 5 Levels of
Difficulty - CRISPR
WIRED
24 May 2017
Biologist Explains One Concept in 5 Levels of Difficulty
Video CRISPR | WIRED 24 May 2017
YouTube
https://www.youtube.com/watch?v=sweN8d4_MUg
biotechnology breakthrough >
gene-editing technology >
Crispr-Cas9 UK / USA
CRISPR, which
stands for
Clustered Regularly Interspaced
Short Palindromic Repeats,
is the
basis for a revolutionary
genome-editing technology
that allows
researchers to make
very
precise modifications to DNA.
http://www.npr.org/sections/13.7/2017/06/05/
531537611/crispr-five-ways
The
CRISPR-cas9 technology
allows
scientists
to make precise edits in DNA,
and that
ability could lead
to whole new medical therapies,
research
tools
and even new crop varieties.
http://www.npr.org/sections/health-shots/2016/12/05/
504454201/scientists-battle-in-court-over-lucrative-patents-for-gene-editing-tool
While everyone
welcomes
Crispr-Cas9
as a strategy to
treat disease,
many scientists
are worried
that it could also be used
to alter genes in
human embryos,
sperm or eggs
in ways that can
be passed
from generation to generation.
The prospect
raises fears
of a dystopian future
in which
scientists create
an elite population
of designer babies
with enhanced
intelligence,
beauty or other traits.
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
https://www.npr.org/series/773368439/
the-crispr-revolution
2023
https://www.npr.org/sections/health-shots/2023/12/25/
1219342935/sickle-cell-patients-journey-
leads-to-landmark-approval-of-gene-editing-treatmen
ign: center; line-height:200%">
https://www.npr.org/sections/health-shots/2023/12/08/
1217123089/fda-approves-
first-gene-editing-treatments-for-human-illness
https://www.npr.org/sections/health-shots/2023/10/31/
1208041252/a-landmark-gene-editing-treatment-for-sickle-cell-disease-
moves-closer-to-realit
2022
https://www.npr.org/sections/health-shots/2022/12/13/
1140384354/crispr-improves-cancer-immunotherapy-car-t-cell
https://www.nytimes.com/2022/12/09/
opinion/crispr-gene-editing-cures.html
https://www.nytimes.com/2022/06/27/
science/crispr-science-medical-research.html
2021
https://www.npr.org/sections/health-shots/2021/09/29/
1040879179/vision-loss-crispr-treatment
https://www.npr.org/sections/health-shots/2021/06/26/
1009817539/he-inherited-
a-devastating-disease-a-crispr-gene-editing-breakthrough-stopped-it
https://www.npr.org/sections/health-shots/2021/05/10/
993656603/blind-patients-hope-
landmark-gene-editing-experiment-will-restore-their-vision
https://www.npr.org/sections/health-shots/2021/03/08/
974751834/crispr-scientists-biography-
explores-ethics-of-rewriting-the-code-of-life
2020
https://www.npr.org/sections/health-shots/2020/12/15/
944184405/1st-patients-to-get-crispr-gene-editing-treatment-continue-to-thrive
https://www.npr.org/2020/03/18/
817811768/yep-they-injected-crispr-into-an-eyeball
https://www.npr.org/sections/health-shots/2020/03/04/
811461486/in-a-1st-scientists-use-revolutionary-gene-editing-tool-to-edit-inside-a-patient
2019
https://www.npr.org/sections/health-shots/2019/12/25/
784395525/a-young-mississippi-womans-journey-through-a-pioneering-gene-editing-experiment
https://www.npr.org/sections/health-shots/2019/11/19/
780510277/gene-edited-supercells-make-progress-in-fight-against-sickle-cell-disease
https://www.npr.org/sections/health-shots/2019/11/06/
776169331/crispr-approach-to-fighting-cancer-called-promising-in-1st-safety-test
https://www.npr.org/2019/11/01/
775332170/a-revolutionary-experiment-to-edit-human-genes
https://www.nytimes.com/2019/10/28/
health/crispr-genetics-antibiotic-resistance.html
https://www.theguardian.com/commentisfree/2019/oct/22/
gene-editing-crispr-scientists
https://www.npr.org/sections/health-shots/2019/10/21/
771266879/scientists-create-new-more-powerful-technique-to-edit-genes
https://www.npr.org/sections/health-shots/2019/10/10/
766765780/after-a-life-of-painful-sickle-cell-disease-a-patient-hopes-gene-editing-can-hel
https://www.npr.org/sections/health-shots/2019/09/11/
759369190/crispr-gene-editing-may-offer-path-to-cure-for-hiv-first-published-report-shows
https://www.npr.org/sections/health-shots/2019/08/22/
746321083/scientists-attempt-controversial-experiment-to-edit-dna-in-human-sperm-using-cri
https://www.npr.org/sections/health-shots/2019/07/29/
744826505/sickle-cell-patient-reveals-why-she-is-volunteering-for-landmark-gene-editing-st
https://www.nytimes.com/2019/11/06/
health/crispr-cancer-leukemia.html
https://www.npr.org/sections/health-shots/2019/11/06/
776169331/crispr-approach-to-fighting-cancer-called-promising-in-1st-safety-test
https://www.npr.org/sections/health-shots/2019/05/22/
723582726/scientists-modify-viruses-with-crispr-to-create-new-weapon-against-superbugs
https://www.npr.org/sections/health-shots/2019/04/17/
714121698/gene-therapy-advances-to-better-treat-bubble-boy-disease
https://www.npr.org/sections/health-shots/2019/04/16/
712402435/first-u-s-patients-treated-with-crispr-as-gene-editing-human-trials-get-underway
https://www.theguardian.com/science/video/2019/mar/28/
the-biggest-revolution-in-gene-editing-crispr-cas9-explained-video
https://www.theguardian.com/science/2019/mar/13/
scientists-call-for-global-moratorium-on-crispr-gene-editing
https://www.theguardian.com/science/2019/mar/02/
nessa-carey-interview-china-gene-editing-big-pharma-100000-genomes-project
https://www.npr.org/sections/goatsandsoda/2019/02/20/
693735499/scientists-release-controversial-genetically-modified-mosquitoes-in-high-securit
https://www.npr.org/sections/health-shots/2019/02/01/
689623550/new-u-s-experiments-aim-to-create-gene-edited-human-embryos
2018
https://www.npr.org/sections/health-shots/2018/12/07/
673878474/outrage-intensifies-over-claims-of-gene-edited-babies
https://www.nytimes.com/2018/12/05/
health/crispr-gene-editing-embryos.html
https://www.npr.org/sections/health-shots/2018/11/26/
670752865/chinese-scientist-says-hes-first-to-genetically-edit-babies
https://www.npr.org/sections/health-shots/2018/02/21/
585336506/doctors-in-china-lead-race-to-treat-cancer-by-editing-genes
2017
https://www.npr.org/sections/health-shots/2017/12/20/
571208704/scientists-use-gene-editing-to-prevents-a-form-of-deafness-in-mice
http://www.npr.org/sections/13.7/2017/06/05/
531537611/crispr-five-ways
http://www.npr.org/sections/alltechconsidered/2017/05/27/
530210657/how-a-gene-editing-tool-went-from-labs-to-a-middle-school-classroom
http://www.npr.org/sections/health-shots/2017/02/15/
515459773/broad-institute-wins-big-battle-over-crispr-gene-editing-patent
https://www.npr.org/2017/01/12/
509482815/new-gene-editing-techniques-hold-the-promise-of-altering-the-fundamentals-of-lif
2016
http://www.npr.org/sections/health-shots/2016/12/05/
504454201/scientists-battle-in-court-over-lucrative-patents-for-gene-editing-tool
http://www.npr.org/sections/health-shots/2016/11/02/
500331130/science-rewards-eureka-moments-except-when-it-doesnt
2015
http://www.nytimes.com/2015/12/04/
science/crispr-cas9-human-genome-editing-moratorium.html
http://www.nytimes.com/2015/11/15/
magazine/the-crispr-quandary.html
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
gene-editing technology >
Crispr-Cas9 > agriculture, farming
https://www.nytimes.com/2020/01/08/
magazine/gene-drive-mosquitoes.html
https://www.nytimes.com/2019/06/17/
science/food-agriculture-genetics.html
https://www.nationalgeographic.com/environment/
future-of-food/food-technology-gene-editing/ - Aug. 10, 2018
https://www.nytimes.com/2018/10/05/
science/groundcherries-crispr-gene-editing.html
https://www.nytimes.com/2017/01/09/
science/genetically-edited-foods-crispr.html
https://www.nytimes.com/2015/11/27/
us/2015-11-27-us-animal-gene-editing.html
CRISPR > blind patients > restore
vision USA
https://www.npr.org/sections/health-shots/2021/05/10/
993656603/blind-patients-hope-landmark-gene-editing-experiment-will-restore-their-vision
modify DNA > gene-editing tool >
CRISPR >
patients with vision loss see color again
USA
https://www.npr.org/sections/health-shots/2021/09/29/
1040879179/vision-loss-crispr-treatment
CRISPR
gene-editing tool USA
https://www.npr.org/sections/health-shots/2019/02/01/
689623550/new-u-s-experiments-aim-to-create-gene-edited-human-embryos
a CRISPR
gene-editing breakthrough USA
https://www.npr.org/sections/health-shots/2021/06/26/
1009817539/he-inherited-a-devastating-disease-
a-crispr-gene-editing-breakthrough-stopped-it
enzyme
It's called
CRISPR-Cas9.
And the Cas9 part
is an enzyme.
And enzymes are
basically things that cut.
And it's a
scalpel.
It's a molecular
scissors.
So you put those
two things together.
You program
CRISPR to go where you want.
And when it gets
there,
it cuts the very
pieces of DNA you want cut.
It's remarkably
precise.
It works with
great efficiency.
There are - it is
not 100 percent perfect.
We can talk about
that.
But it's more
efficient and more successful
than any such
tool there had ever been
or any that
anyone had envisioned.
https://www.npr.org/2017/01/12/
509482815/new-gene-editing-techniques-
hold-the-promise-of-altering-the-fundamentals-of-lif
biotechnology breakthrough
gene-editing technology >
gene-edited babies USA
https://www.npr.org/sections/health-shots/2018/12/07/
673878474/outrage-intensifies-over-claims-of-gene-edited-babies
create genetically modified babies using CRISPR
USA
https://www.npr.org/sections/health-shots/2018/11/26/
670752865/chinese-scientist-says-hes-first-to-genetically-edit-babies
create gene-edited human embryos
USA
https://www.npr.org/sections/health-shots/2019/02/01/
689623550/new-u-s-experiments-aim-to-create-gene-edited-human-embryos
Jennifer A.
Doudna
biochemist
at the University of California,
Berkeley
(who) helped make one
of the most monumental
discoveries in biology:
a relatively easy way
to alter any organism’s
DNA,
just as a computer user
can edit a word in a
document.
The discovery
has turned Dr. Doudna
(the first syllable rhymes with loud)
into a
celebrity of sorts,
the recipient of numerous
accolades and prizes.
The so-called Crispr-Cas9
genome editing
technique
is already widely used
in laboratory studies,
and scientists hope
it may one day help
rewrite
flawed genes in people,
opening tremendous new possibilities
for
treating, even curing, diseases.
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
http://www.nytimes.com/2015/11/15/
magazine/the-crispr-quandary.html
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
editing the human
genome / genome editing
Genome editing
is
a powerful procedure
that has already
been a game-changer
in helping scientists to understand
the
roles of genes
in health and diseases.
It coopts the
natural immune
defences of bacteria
to create what is
often described
as “molecular scissors”.
These can cut
out, but also replace,
strands of DNA with great precision.
It is possible to
change
single letters of
the DNA code.
http://www.theguardian.com/science/2015/sep/02/
genome-editing-how-to-modify-genetic-faults-and-the-human-germline
http://www.nytimes.com/2015/12/04/
science/crispr-cas9-human-genome-editing-moratorium.html
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
http://www.theguardian.com/science/2015/sep/02/
genome-editing-how-to-modify-genetic-faults-and-the-human-germline
https://www.youtube.com/watch?v=-sU2HrmZ-7s - 18 August 2015
http://www.nytimes.com/2015/05/12/
science/jennifer-doudna-crispr-cas9-genetic-engineering.html
http://www.npr.org/blogs/health/2015/03/20/
394311141/scientists-urge-temporary-moratorium-on-human-genome-edits
http://www.nytimes.com/2015/03/20/
science/biologists-call-for-halt-to-gene-editing-technique-in-humans.html
Related > Anglonautes >
Vocapedia
genetics
sickle cell disease
genetically modified (GM) food,
edited food
infectious
diseases > malaria
body,
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viruses, bacteria,
diseases / illnesses,
hygiene, sanitation,
health care / insurance
mental health, psychology
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contraception, abortion,
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